Key Benefits

NIKKISO´s long standing experience in the development and production of dialysis membranes is reflected in the quality of our FD-Series dialysers.

The PEPA® – membrane with its chemical and geometric structure was developed by NIKKISO and can be produced with two different properties. The specific proportion of PVP polymer increases the hydrophilic properties of the membrane. The optimised inner diameter of the hollow fibers ensures a low bloodside pressure drop, and the membrane thickness of 30 um provides good diffusion properties. In this way, the most important requirements of a modern dialyser are met.

The specially developed asymmetric 3-layer structure of the PEPA® – membrane provides excellent protection against endotoxins and their fragments. A thin skin layer on the dialysate side is an initial line of defence that blocks endotoxins and endotoxin fragments. The asymmetric porous structure guarantees a high level of mechanical strength and can adsorb endotoxin fragments thanks to its adsorptive properties. The thin skin layer on the blood side completes the triple safety system.

Using a fluorescent labelled endotoxin marker in laboratory tests, it has been shown that endotoxins are safely retained on the dialysate side.

* M. Hayama, et al., Optimum dialysis membrane for endotoxin blocking., J. Membr. Sci., 219 (2003), 15-25

Super High-Flux FDY Series

The wet type FDY-Series was developed for applications that require an extended sieving coefficient profile. With these dialysers, the hemodiafiltration mode can be used effectively to remove protein-bound toxins. The chemical structure of the membrane and the excellent blood compatibility properties are similar to those of the FDX-series.


For further information please download our product brochure in PDF format:


Consult your local representative for availability in your region

A drug-registered version of Accusol is available in certain countries. For further information please contact your local Nikkiso representative or email